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The review documented DSIP's widespread distribution throughout the brain and peripheral tissues, its remarkably stable presence in cerebrospinal fluid, and its unusually long-lasting biological effects despite a short plasma half-life of only minutes

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These observations are corroborated at the molecular level, with dysregulation in the expression of pro-proliferative proteins (e.g., cyclin D1) and tight junction proteins (e.g., zonula occludens-1, occludin, and claudin 1, 4, and 8) (Birder, 2019)

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