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The CVB3 cardiomyophilic strain virus (CVB3m) and the CVB3 non-cardiomyophilic strain virus (CVB3o) are variants of the CVB3 standard strain, which can be adapted for different research objectives to achieve the required pathology of myocarditis in specific tissue types ( Viral entry into the myocardium results in three kinds of responses

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Impact of GEP44 and GEP12 on food intake and body weight in DIO rats compared to responses to Ex-4 Data from the dose escalation experiment conducted in DIO rats indicated that treatment with low doses (0.5 to 10 nmol/kg/d) of GEP44 and Ex-4 resulted in similar anorectic effects (Fig

Following tumor resection (Fig

This is suggestive but not demonstrative that GIPR agonism reduces the GI AE incidence associated with GLP-1R agonism

Taking into account available data concerning the alkylating nature of ethylene oxide, the demonstration of DNA adducts, the overwhelming positive in vivo responses in mutagenic and clastogenic assays, the reproducible positive carcinogenic findings in animals, and the epidemiological findings suggesting an increase in the incidence of human cancer, ethylene oxide should be considered as a probable human carcinogen, and its levels in the environment should be kept as low as feasible