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In the MCT-induced PAH rat model, Blueberry Extract can reduce total reactive oxygen species (ROS), NADPH oxidase activity and lipid oxidation in lung tissues, restore the expression of transcription factor Nrf2, activate downstream antioxidant enzymes, and at the same time correct the balance of endothelin receptors, reducing ET-1-mediated inflammatory vascular remodeling (Turck et al., 2020

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The E1 gene (symbol: BCKDHB) is located on chromosome 6q14.1 and is composed of 21 exons that generate three alternatively spliced mRNAs that collectively encode a 392 amino acid protein (isoform 1 ) and a 322 amino acid protein (isoform 2)