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This is a reasonable position, and it is one of the arguments the July panel will need to weigh carefully against the absence of rigorous human trial data

Food Nutrition Bulletin 29 (2_Suppl

G.RoglianiP.et al (2016)

Immunol Invest 48(2):198209 Bartalena L, Piantanida E, Gallo D, Ippolito S, Tanda ML (2022) Management of Graves hyperthyroidism: present and future

Because it is not renally filtered as an intact molecule in the same way small organic drugs are, its renal contribution is considered indirect, though the full elimination profile in humans has not been formally characterized

Theoretical concerns exist that excessive angiogenesis could promote cancer growth, although this has not been proven in human studies