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Lithium remains the first-line therapy for manic-depressive illness, bipolar disorder 14 , traumatic brain injury 15 , and numerous neurodegenerative diseases, such as Alzheimers, Huntingtons, and Parkinsons diseases 16

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However, clinical innovations are emerging in the use of progesterone receptor modulators as a medical therapy

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This rebound is predictable and dose-dependent: higher doses typically create stronger suppression, so cessation from high doses produces more noticeable hunger increases