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Malhan also says there may be metabolic elements involved, too

In the context of pelvic radiotherapy, the depletion of barrier-supportive commensals and the expansion of inflammatory pathobionts are recurring features of dysbiosis, positioning Bifidobacteria as mechanistically plausible candidates to mitigate radiation enteritis by restoring mucosal resilience 86

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Epigenetic regulation by lncRNA is associated with the recruitment of chromatin modifiers to steroidogenic gene loci which influences their transcriptional output