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The date is written on the label

Payers want to see that the prescriber is following the FDA-approved escalation protocol: starting at 2.5mg weekly for 4 weeks, then increasing to 5mg weekly, with subsequent increases as clinically indicated

See Section 1c for comments about choice of conditions

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The goal is to give you the same temperature a thoughtful physician brings to the room when this conversation comes up

10.1016/j.neulet.2016.02.009 16 BulteauA