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Advertisement Research ArticleEndocrinologyMetabolism Open Access | 10.1172/JCI184636 1 Monell Chemical Senses Center, Philadelphia, Pennsylvania, USA

Joshi GP, Abdelmalak BB, Weigel WA, Soriano SG, Harbell MW, Kuo CI, Stricker PA, Domino KB, American Society of Anesthesiologist (ASA) Task Force on Perioperative Fasting: American Society of Anesthesiologists consensus-based guidance on preoperative management of patients (adults and children) on glucagon-like peptide-1 (GLP-1) receptor agonists

In short, antioxidants keep free radicals from running wild, and glutathione levels are a determining factor in keeping free radicals in check and detoxification

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With age, free radical production increases oxidative damage to the mitochondria, which can potentially decrease energy production