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Non-union site debridement increased the efficacy of rhBMP-2 in a rodent model

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By accurately quantifying loading efficiency and encapsulation efficiency , we demonstrate the superior payload capacity often achieved with active loading, justifying the process complexity for amphiphilic weak bases like doxorubicin

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doi: 10.1210/jcem.87.6.8739 46

This has earned methylene blue a Category X safety label in pregnancy, which will terrify everyone but please bear in mind that the Category X warning really applies to intra-amniotic injection of methylene blue