Berberine directly affects the gut microbiota to promote intestinal farnesoid X receptor activation
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Clinically, this means results often look like a delayed curve, rather than an absent one
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At 6 or 12 months, depending on the progress made, the doctor might recommend keeping the same dose if there is no slowing of the weight loss, or if there is no further improvement for some time, so you may be switched to a higher dose