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Importantly, along with improved glucose clearance, significantly lower insulin levels during OGTT were observed in KBP-089 (1.25 and 2.5 g/kg) and combination therapy groups, indicating improved insulin sensitivity

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These processes are influenced by endoplasmic reticulum (ER) stress, oxidative stress, mitochondrial dysfunction, and islet inflammation (Maria et al., 2020

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[2] Ikeda N, Loomba RS, Patel R, Dorsey V, Yousaf F, Nelson-McMillan K