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A meta-analysis of clinical trials found that the use of pioglitazone, a TZD, was associated with significant improvements in depressive symptoms

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35 Similarly, in a recent study of obese individuals without diabetes, Louis et al demonstrated that tirzepatide (10 or 15 mg) resulted in significantly greater weight loss than semaglutide (1.7 or 2.4 mg) over a 72-week period

In that research, this pairing, breakdown of damaged material alongside stimulation of new matrix production, is described as a coordinated and beneficial part of tissue repair, not a harmful side effect