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The interaction between TNF and its receptors is prevented by binding TNF with the antibody

Statin-associated muscle symptoms (SAMS) are the most common toxicity of statins, as shown by manifestations of myalgia, myopathy, myositis with increased creatine kinase (CK), or rhabdomyolysis (Ward et al., 2019), and SAMS risk appears to link with systemic exposure to higher doses of statins (Armitage et al., 2010)

Lancet Neurology 21 (9), 843856

In addition, DM can cause abnormal sperm motility, testicular alterations, decreased libido, impotence, erectile dysfunction, and hormone abnormalities that result in subfertility and infertility in men []

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