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Upregulation of AQP4 Improves Blood-Brain Barrier Integrity and Perihematomal Edema Following Intracerebral Hemorrhage

Promising strategies include biomarker-guided, dual-immunotherapy combinations selected based on features like high tumor immunogenicity [261], Another approach involves the systemic remodeling of the immunosuppressive niche, for instance by neutralizing key microenvironmental factors such as GDF-15 to reinvigorate antitumor immunity [262], In summary, these converging technological advancesspanning precise monitoring, mechanism-informed therapy, and intelligent therapeutic sequencingcollectively provide the tools to systematically deconstruct the integrated biological networks that sustain MDR

S6 Effect of ibuprofen-coupled non-targeted (3-PLG-ibu) and alanine-glutathione-targeted (3-PLG-ibu-A-GSH) nanocarriers on the viability of human brain endothelial cells

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Kupper, T