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If your appetite drops dramatically and you cut calories too aggressively, fatigue is the natural result

Dipeptidyl peptidase 4 inhibitor sitagliptin protects endothelial function in hypertension through a glucagon-like peptide 1-dependent mechanism

If this approach truly worked, wed see far more research and legitimate medical products using it, but right now, the science doesnt support the claims

Lancet Diab Endocrinol 6(3):237248 Ethics declarations Disclosures Dr

Smaller, more frequent meals may be better tolerated than large portions, especially during the initial titration phase when side effects are most common