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The study found that proline at position 3 was important for this interaction

As expected, significant amounts of the toxicant were measured in the CSF in vehicle-treated animals, reaching a 30 M concentration after 5 min of perfusion

10.1007/s10787-017-0358-8 12 Berkopic CesarL.GojkovicS.KrezicI.MalekinusicD.ZizekH.Batelja VuleticL.et al (2020)

Any bacteria in the air or on the needle can enter the vial

Chang SC, Lin PC, Lin JK, Yang SH, Wang HS, Li AF