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High levels of NO adversely affect sperm, embryos, implantation, and oviductal function, indicating that reduction in the peritoneal fluid NO production or blocking NO effects may improve fertility in women with endometriosis [23]

The degeneration of neurons in the ventral tegmental area, accompanied by reduced dopamine release and impaired connectivity in target regions, is recognized as a key feature of the early stages of AD, preceding even the formation of A plaques