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SGLT-2 is expressed in the proximal tubule and mediates re-absorption of ~90% of filtered glucose Rx of Heart Failure : There is accumulating evidence for numerous additional mechanisms of action separate from SGLT2 inhibition that may underlie the ability of gliflozins to produce favorable outcomes in the treatment of heart failure

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10.3390/pharmaceutics16101252 316 WoodcockM

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Measurements of heart health, including blood pressure and cholesterol levels, also returned to their original levels after 1.4 years

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