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Verma P, Kunwar A, Indira Priyadarsini K (2017) Effect of low-dose selenium supplementation on the genotoxicity, tissue injury and survival of mice exposed to acute whole-body irradiation

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High-dose intraperitoneal N-acetylcysteine (800 mg/kg) induced acute liver, kidney, and spleen damage in mice, leading to mortality

In addition, NSAID-induced enteropathies can involve excessive translocation of luminal contents such as bacteria and their products, bile acids and pepsin, promoting immune activation and ulceration of the intestinal epithelium (Reuter et al