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However, their long life-span, penetration through the bloodbrain barrier (BBB) 13 , and high therapeutic doses may allow them to directly act on central nervous system GLP-1Rs 12 , thereby causing CNS-dependent side effects

Clinical and Preclinical Dose Ranges in Published Research Most Dihexa research uses rodent models, with doses scaled allometrically to approximate human-equivalent exposures

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The tissue damage is clear and recent, and the body needs strong prompts to mobilize its repair resources effectively

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