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In 1830, Andral and Cruveilhier first reported melanosis of the large intestine and suggested that it was related to the deposition of lipofuscin in the lamina propria of the large intestine

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In this review, aging refers to the biological aging process, healthy aging denotes the preservation of functional and circadian integrity, and circadian disruption describes pathological alterations or misalignment of circadian rhythms

NMR data were collected at 298 K on a Bruker Avance Neo 600-MHz spectrometer using the Bruker Topspin 4.0 software

This critical molecule is instrumental in protecting our cells from oxidative stress, detoxifying our bodies, and supporting immune function