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The general principle described in clinical teaching is to establish a baseline, recheck IGF-1 after the early weeks of any protocol, keep it within an age-appropriate reference range rather than pushing it into supraphysiologic territory, and monitor fasting glucose in at-risk patients

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50 showed that patients treated with Gn-RH agonists experienced significantly more major cardiovascular and cerebrovascular events than those treated with Gn-RH antagonists

Rose and Witebsky(5) showed that immunization of rabbits with extracts of rabbit thyroids produced histologic changes in the thyroid glands resembling those seen in Hashimoto's thyroiditis

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