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This study enrolled 338 adults with obesity and evaluated multiple dose levels over 48 weeks

This is a small population, but the pattern of recurrent, stereotyped vomiting episodes should prompt specialist referral rather than continued dose escalation

All GLP-1 pathway compounds carry the class boxed warning for thyroid C-cell tumor risk

With reduced appetite and calorie intake,preserving muscle mass becomes essential

Bourke SL, Schlag AK, OSullivan SE, Nutt DJ, Finn DP

Involvement of lipophagy and chaperone-mediated autophagy in the pathogenesis of non-alcoholic fatty liver disease by regulation of lipid droplets