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Raw FASTQ files were trimmed with Cutadapt (part of Trim Galore) and aligned to the Gencode GRCh38 Release 43 reference using STAR

Semaglutide injections are convenient and relatively painless

Its a GLP-1 receptor agonist, which mimics a hormone that targets areas in the brain regulating appetite and food intake

In its early form, lentigo maligna, the cancer has not yet spread

Dual-action control: HRT helps prevent the physical buildup of visceral fat, while GLP-1s quiet the mental food noise, making it easier to stay consistent with healthy habits

Culture medium was comprised of Dulbeccos Modified Eagle Medium (DMEM) containing 25 mM glucose, 10% fetal bovine serum (FBS), 100 units ml 1 penicillin G, and 100 g/ml streptomycin