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11 Despite the promise of these medications, they are accompanied by significant risks, including gastrointestinal issues, pancreatitis, kidney failure, gallbladder disease, and thyroid cancer

Preiss D, Dawed A, Welsh P et al (2017) Sustained influence of metformin therapy on circulating glucagon-like peptide-1 levels in individuals with and without type 2 diabetes

They differ in their approved indications, dose escalation and study populations

6 The combination of biomechanical and histological endpoints in this model strengthens the mechanistic interpretation: the structural improvement was accompanied by the expected tissue-level changes predicted by the angiogenic and FAK-paxillin mechanisms

Plaintiffs moved the court to require claimants to establish general causation of a disease only, rather than specific causation. Thus, a plaintiff would need to establish that exposure to the toxic water was as likely as not to cause their disease

doi: 10.1038/s41467-023-42322-2