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Caadas-Garre M, Anderson K, McGoldrick J, et al
Biological plausibility and experimental findings are not the same thing as proven clinical benefit
7A iii)
For acute injuries, some practitioners recommend up to 500750mcg daily for the first 12 weeks, then reducing to 250500mcg for maintenance
Key areas of investigation include: Gastrointestinal : Demonstrated protection against NSAID-induced ulcers, inflammatory bowel disease models, and esophageal damage in multiple animal studies Musculoskeletal : Accelerated healing of transected Achilles tendons, quadriceps muscles, and medial collateral ligaments in rat models Neurological : Neuroprotective effects in models of traumatic brain injury, nerve crush injury, and dopaminergic system damage Organ protection : Hepatoprotective, cardioprotective, and nephroprotective effects demonstrated in various toxicity models The primary limitation is that all evidence comes from animal models
Loss-of-function mutations in YY1AP1 Lead to grange syndrome and a fibromuscular dysplasia-like vascular disease
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