In autoimmune hair loss conditions like alopecia areata where the immune system mistakenly attacks hair follicles T1 helps recalibrate immune function rather than simply suppressing it
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It upregulates 1,584 genes associated with tissue repair, stem cell biology, and antioxidant defense, while downregulating 2,550 genes linked to inflammation, fibrosis, insulin resistance, and cancer metastasis
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doi: 10.2174/1567205010666131212110148 70 GudarziS
Subcellular fractionation revealed reductions in the cytosolic levels of G1 and arrestin3, and corresponding increases in G1 nuclear levels (Fig