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Some studies report increases in TMAO after supplementation in certain people, and the longterm cardiovascular significance of that finding remains an open research question.

Differences in trial duration, drug exposure, target engagement and outcome sensitivityall may have factored in

Current Opinion in Gastroenterology, 36(3), 264-271

Highly recommend for those men needing a little extra energy. - Henry W

Semaglutide is approved for chronic weight management and can be used long-term under medical supervision

Rahman MM, Islam F, -Or-Rashid MH, Mamun AA, Rahaman MS et al (2022) The gut microbiota (microbiome) in cardiovascular disease and its therapeutic regulation