This period, following the completion of pubertal development up to young adulthood, involves the transfer of patients from pediatric to adult healthcare services and requires careful attention to provide continuous care and appropriate management of age-specific health issues
The STEP 4 withdrawal trial demonstrated that discontinuation of semaglutide 2.4 mg after a 20-week run-in is followed by nearly complete weight regain within one year an outcome that is more accurately framed as disease recurrence in a chronic relapsing condition than as drug failure (Quimbayo-Cifuentes, 2026)
Journal of Clinical Endocrinology & Metabolism , 105(3), e123-e138
Uh, in animal studies they injected ginormous doses and it didn't have any severe toxic or lethal effects
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Ethics approval for animal experimentation was obtained from Washington State University