Preparations were superfused at a rate of 3.0 ml/min with the following artificial cerebrospinal fluid (ACSF) [19] (in mM): 124 NaCl, 5.0 KCl, 1.2 KH 2 PO 4 , 2.4 CaCl 2 , 1.3 MgCl 2 , 26 NaHCO 3 and 30 glucose, equilibrated with 95% O 2 and 5% CO 2 , pH 7.4, at 2627 C
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PMC 387830
Herein, OA is a prime example of stress-associated joint disorder due to the constant and intense mechanical strain on the joints ( The aim of this review is, therefore, to (i) briefly summarize current knowledge on the pathogenesis of OA focusing on the (patho-)physiology of the synovial tissue, (ii) provide an overview of possible mechanisms of fibroblast to myofibroblast transformation in OA and (iii) outlines their metabolic alterations that improve our understanding of new potential therapeutic targets
copper peptides are gentler and rebuild structure with less irritation