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However, for patients identified preoperatively with severe malnutrition or a high inflammatory state, a more aggressive nutritional strategy may be required, such as early combination with parenteral nutrition (PN) to ensure adequate energy and protein supply, or more cautious selection of feeding tube routes to balance the benefits of enteral nutrition with the risk of aspiration (120)

Future studies are needed to compare the clinical impact of GLP-1RA, in terms of NNT, with other therapies in the pipeline that target the various pathways in the ASCVD process, such as bempedoic acid which has been associated with reduced risk of MI and coronary revascularization due to the improvement in lipid and inflammatory profiles [77]