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Losing muscle can slow progress and make it harder to keep weight off

Tier 3: Obesity / Weight Loss Optional, Covered in 13 States as of January 2026 Weight loss drugs occupy a unique statutory category

Small blood vessels under the skin can break when the needle penetrates, producing a bruise, hematoma, or petechiae

Currently, there are other dual GIPR/GLP-1R agonists available, such as GLP-1R/GR (glucagon receptor), GLP-1R/AR (amylin receptor), and GLP-1R/NPYR (peptide YY binds to neuropeptide Y receptors) [36, 115] and even triple agonists that can activate GIPR to treat obesity and T2DM

PubMed Central, Hira, Tohru, et al

Targeting multiple hormonal systems simultaneously may offer additive benefits in weight reduction and metabolic improvement that neither agent could achieve alone