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Effects of alpha-tocopherol and beta-carotene supplementation on cancer incidence and mortality: 18-year postintervention follow-up of the Alpha-tocopherol, Beta-carotene Cancer Prevention Study

Biochemically, once ferroptosis is activated, it cannot be suppressed by apoptosis, necrosis, or autophagy inhibitors but can be hidden by iron chelators such as deferoxamine (DFO) or antioxidants such as Trolox and fer-1

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Delivery Considerations: Research compounds are commonly administered by injection in laboratory settings

All analyses were performed within the TriNetX platform, which computes frequencies, summary statistics, covariate balance diagnostics, and outcome models using embedded statistical modules