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Basal IRE1 activity is essential for pancreatic islet growth and oxidative stress resistance (Hassler et al

[1] [2] Systemic symptoms such as fatigue and headache are also recognised, and these may contribute to a flu-like feeling, especially when combined with reduced caloric intake and the body's adjustment to weight loss

While this can feel like the medication is failing, it is actually a normal part of how the drug is processed

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In rare cases, excessive sweating can signal an underlying metabolic imbalance or interaction with another medication