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It is FDA-approved for Type 2 diabetes but is sometimes prescribed off-label for weight loss

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When AOD-9604 binds to or modulates these receptors, it preferentially activates fat cells while having minimal effects on other tissues that primarily express beta-1 and beta-2 adrenergic receptor subtypes

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The mice in that study had GLP-1 effects targeted to muscle , whereas in humans the medications predominantly act on the pancreas, brain, and gut

People who lose weight very quickly without concurrent strength training, physical therapy, or gradual activity progression report more frequent musculoskeletal complaints than those who combine medication with structured exercise