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Based on phase 2 inclusion criteria and the expected prescribing profile once approved, likely candidates include adults with BMI 30 kg/m or greater, adults with BMI 27 kg/m or greater with at least one weight-related comorbidity (per the obesity pharmacotherapy framework in the 2023 AHA/ACC/AAPA/ABC/ACPM/ADCES/AHNHA/AMA/ASH/ASPC/NHLBI/PCNA Guideline for Cardiovascular Risk Reduction) [16], and adults with biopsy-confirmed or imaging-confirmed MASLD or MASH where liver fat reduction is a treatment target

10.1212/WNL.0b013e3181ffe4f6 Neurology 161 SecherA.JelsingJ.BaqueroA

Common Side Effects Most people taking GLP-1 agonists experience mild side effects as their bodies adjust to the medication

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The clinical study was promoted by the Assistance Publique-Hpitaux de Paris (APHP) and Direction of Clinical research, which promoted the clinical investigations (Microbaria and LEAKY GUT projects)