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But some people should not take this drug: those with kidney problems or heart failure, for example

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CD47 the surface protein CD47 is a receptor that binds to signal-regulatory protein alpha (SIRP) or thrombospondin-1 (TSP-1) and acts as a signal to inactivate the phagocytosis in macrophages

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For instance, in a study of early worsening of DR after intensive insulin treatment, pancreas transplant, or bariatric surgery, 2 10% to 20% of patients had worsening of DR within three to six monthswith twice that many for patients who already had advanced DR at baseline

Mortality was assessed using univariate and multivariate logistic regression analysis