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Nat Med 22:8490

The increased energy expenditure from glucagon activation may help preserve lean mass compared to approaches that rely primarily on appetite suppression, though this hypothesis requires further study

A mean reduction in body weight of 7% in participants following a low-energy diet resulted in significantly more patients responding (according to reduction in PASI score) to low-dose ciclosporin [17]

That matters because GLP-1 treatment is not one-size-fits-all

They enhance insulin secretion, suppress glucagon release, slow gastric emptying, and promote satiety