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Mouse studies reported changes in liver fat, inflammation and histology

In gout models, elastic liposomes improved colchicine efficacy by increasing stratum corneum permeation, sustaining drug release to reduce MSU crystal-induced exudate volume and leukocyte infiltration, and inhibiting collagen deposition/inflammatory cell accumulation (Singh et al., 2009)

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Navarro-Lobato and Genzel, 2018)

The consent form should specify the recommended frequency and expected duration so patients understand long-term commitment

Margis R, Dunand C, Teixeira FK, Margis-Pinheiro M