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An entirely separate candidate gene study involving 275 patients who had suffered acute liver failure after either deliberate or accidental APAP overdose also reported some borderline significant associations.68 For the rs1467558 CD44 variant discussed above, there was a trend towards significance in those who had overdosed unintentionally

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Under a hyperglycemic condition, ROS accumulates, damages DNA and proteins, and injures cardiomyocytes

For oral vs injectable route evidence, see BPC-157 Oral vs Injectable