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Williams WP 3rd, McLin DE 3rd, Dressman MA, Neubauer DN

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3,4 The effect of UVR on DNA is accredited to the DNA nucleobases of irradiated cells absorbing photons in the UV region, resulting in several cytosolic effects, mutagenic DNA lesions and DNA strand breaks

reported that lipid peroxidation product 4-HNE inhibited pyroptosis and inflammasome activation of LPS stimulated macrophages (M1 macrophage) by directly disrupting the binding of NIMA-related kinases 7 to NLR Family Pyrin Domain Containing 3 (NLRP3) (72)

doi: 10.1073/pnas.92.19.8759

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