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While more expensive, the proven effectiveness often provides better value
Within the clinical trial setting, retatrutide has been associated with a range of adverse effects, the majority of which are gastrointestinal in nature
In small proof-of-concept phase 2 randomized controlled trials (RCTs) in patients with biopsy-confirmed MASH, liraglutide at 1.8 mg/day for 48 weeks (201), semaglutide at 0.4 mg/day for 72 weeks (202), and tirzepatide at 15 mg/week for 52 weeks (203) have been reported to achieve placebo-corrected percentages of participants meeting the criteria for resolution of MASH without worsening fibrosis by 30% (P = 0.019), 42% (P 10%) may lead to diabetes remission (237)
Plan administrators focus on whether the medication addresses medical care, not general wellness or appearance-related goals
A., Weir-Restrepo, D., Izquierdo-Condoy, J
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