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A Phase 3 diabetes trial is also ongoing as part of the submission package

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The efficacy and cost-effectiveness of endoscopic surveillance versus at-need endoscopy is now being studied in the multicentre randomised controlled BOSS trial

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In patients with endometriosis, progesterone resistance is observed, possibly related to a decrease in PRB levels [86], which tends to inactivate progesterone target genes, leading to inflammation and deficient estrogen metabolism [87]

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