GLP-1R activity also promotes the transactivation of epidermal growth factor receptor (EGFR), which then signals through phosphoinositide 3-kinase (PI3K) and insulin receptor substrate-2 (IRS-2), and subsequently activates extracellular-signal-regulated kinase 1 and 2 (ERK1/2) and nuclear translocation of PKC to mediate -cell proliferation and differentiation (114)
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However, the active ingredient in Zepbound, tirzepatide, is approved under the brand name Mounjaro to treat type 2 diabetes
Because of this careful introduction and the time it takes for the medication to build up in your system, significant weight loss is not expected during the initial week
They are commonly used in the treatment of type 2 diabetes and, more recently, for weight management