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It is primarily synthesized in the liver, aids in the metabolism of toxins, is involved in DNA synthesis and repair, prevents oxidative cell damage as well as enhances immune system function

The oncometabolite D-2HG produced in IDH-mutant tumors from KG contributes to inhibiting antitumor immunity via the metabolic reprogramming of CD8+ T cells and decreasing their proliferation and antitumor toxicity [100]

Since this lipase is highly conserved across C.acnessubtypes, this research also applies to the acne-associated IA

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Iron overload was thought to play an important contributory role in shaping the EMs inflammatory microenvironment and cell adhesion [6, 15, 27]

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