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High urea and NaCl carbonylate proteins in renal cells in culture and in vivo , and high urea causes 8-oxoguanine lesions in their DNA

The first comes down to diet

References Campanati A, Marani A, Martina E, Diotallevi F, Radi G, Offidani A

Primary and secondary outcomes Primary outcomes The primary efficacy endpoints of the study encompassed the alterations noted in the DAS28-CRP, in conjunction with scores derived from the MHAQ and VAS, assessed from baseline to the conclusion of the 12-week treatment duration

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The whitening or lightening effect comes last since I'm already fair to begin with