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This suggests that activation of mitophagy rescues the mitochondrial dysfunction in aged hair follicles, restores the self-repairing ability of aged hair follicles, activates the proliferation of HFSCs, and promotes hair regeneration

Defects in SDH subunits lead to succinate accumulation and oncometabolite-driven pseudohypoxia and are strongly linked to hereditary paragangliomas, pheochromocytomas and certain renal cell carcinomas, underscoring the essential role of complex II in metabolic and redox homeostasis 78,79

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PMID: 36518525

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