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It exists in two forms reduced glutathione (GSH), which is the active antioxidant form, and oxidised glutathione (GSSG), which is the inactive form created when GSH neutralises a free radical

Nrf2 is involved in not only the regulation of GSH synthesis and reduction via upgrading some enzymes and proteins (SLC7A11, GCLM, GCLC, GR) but also the activation of GSH-dependent antioxidant enzymes (GPX, GST) [200, 201]

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Pickart published 46 articles in peer-reviewed scientific journals and held 29 patents

However, in contrast to the tumour-suppressive effects described above, there is evidence that CDO1 can have a tumorigenic effect associated with aggressive glioblastoma, since its overexpression was detected in these tumours

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