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A study (322) demonstrated that male Sprague Dawley rats administered low (2.6 g/kg/day), medium (5.3 g/kg/day), or high (10.5 g/kg/day) doses of fructose over 20 weeks exhibited elevated serum levels of pro-inflammatory cytokines (IL-6 and TNF-), alongside a reduction in the anti-inflammatory cytokine IL-10