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Stress management affects cortisol levels, with chronic stress elevating catabolic hormones that oppose tissue repair

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Gene expression shifts from tissue destruction to repair patterns with 127 genes altered, upregulating repair genes while downregulating inflammatory genes

Table 3.

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Consistent with the impact of estrous phase on the weight loss response, semaglutide-induced behavioral disruption was also estrous phase-dependent, being greatest during proestrus (Fig